Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-12-04
2007-12-04
Schultz, J. Douglas (Department: 1639)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
10683583
ABSTRACT:
Methods of detecting components of interest, e.g., nucleic acids and sugars, are provided. The methods comprise contacting one or more nanowires comprising a functional group with a sample containing the component or components of interest. In one embodiment, the functional group comprises a hairpin oligonucleotide, e.g., a hairpin that changes conformation upon binding the component of interest, e.g., a nucleic acid. The change in conformation produces a change in charge that is detected. In another embodiment, the functional group comprises an enzyme, e.g., glucose oxidase, which produces a change in pH when glucose is present in a sample.
REFERENCES:
patent: 6331438 (2001-12-01), Aylott et al.
patent: 6716620 (2004-04-01), Bashir et al.
patent: 6733828 (2004-05-01), Chao et al.
patent: 6828786 (2004-12-01), Scherer et al.
patent: 2002/0117659 (2002-08-01), Lieber et al.
patent: 2002/0172963 (2002-11-01), Kelley et al.
patent: 2003/0102510 (2003-06-01), Lim et al.
patent: 2004/0038307 (2004-02-01), Lee et al.
patent: WO 02/48701 (2002-06-01), None
patent: WO 03/085700 (2003-10-01), None
patent: WO 03/085701 (2003-10-01), None
Cui et al., Science 293:1289-1292 (2001).
Zhao et al., 2001, Nucleic Acids Research 29(4):955-959 (2001).
Brand et al., Appl Microbiol Biotechnol 36(2):167-72 (1991).
Dixon et al., (1999) “Anthrax”NEJM341:815.
Owicki and Parce (1992) “Biosensors bases on the energy metabolism of living cells: The physical chemistry and cell biology of extracellular acidification”Biosensors and Bioelectronics7:255-272.
Parce et al., (1989) “Detection of Cell-Affecting Agents with a Silicon Biosensor”Science246:244.
Delvaux et al. (2003) “Immobilisation of glucose oxidase within metallic nanotubes arrays for application to enzyme biosensors”Biosensors and Bioelectronics18: 943-951.
Tiefenauer, et al. (1997) “Towards amperometric immunosensors devices”Biosensors&Bioelectronics12(3): 213-223.
Bock Larry
Daniels R. Hugh
Empedocles Stephen
Filler Andrew L.
Lundgren Jeffrey S
Nanosys Inc.
Quine Intellectual Property Law Group P.C.
Schultz J. Douglas
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