Nanaomycin B and therapeutic compositions containing same

Details Nanaomycin B and therapeutic compositions containing same Nanaomycin B and therapeutic compositions containing same

1979-05-25

1981-12-29

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424283, 2603452, C07D31178

Patent

active

043082106

ABSTRACT:
The present invention relates to new compound designated as nanaomycin B represented by general formula: ##STR1## Nanaomycin B is a quinone type and is active on mycoplasma, Gram-positive bacteria and trycophyton. This compound is useful as a medicament for infectious diseases of humans and animals caused by a parasite of trichophyton or mycoplasma etc. The acute toxicity (LD.sub.50, intra-penetrial injection) in mice of this compound is 169 mg/Kg.
Nanaomycin B is produced by fermentation in which a nanaomycin-producing strain belonging to the genus Streptomyces is cultured in a medium under aerobic conditions and the accumulated nanaomycin B in the cultured broths is recovered therefrom.

REFERENCES:
patent: 3524868 (1970-08-01), Hoeksema
patent: 3632607 (1972-01-01), Meyer

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