NADH oxidase assay for neoplasia determination

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving oxidoreductase

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435 771, 435 692, 435184, C12Q 126, C12N 999

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active

056058101

ABSTRACT:
NADH oxidase is shown to be a target for a variety of uses in diagnosis and therapy. Particularly, the NADH oxidase associated with neoplastic cells is immunologically and biologically different from NADH oxidase associated with normal cells. Thus, the presence of tumor cells in patients can be monitored by monitoring the NADH oxidase of serum. In addition, use of the NADH oxidase associated with tumor cells provides opportunities for assays for screening drugs which are specific for neoplastic cells and can serve as anticancer drugs or growth inhibitors.

REFERENCES:
Abo et al., "Activation of the NADPH Oxidase Involves the Small GTP-Binding Protein p21", Nature 353:668-670 (1991).
Nunoi et al., "Two Forms of Autosomal Chronic Granulomatous Disease Lack Distinct Neutrophil Cytosol Factors", Science 242:1298-1301 (1988).
Sun et al., "Inhibition of Transplasma Membrane Electron Transport by Transferrin-Adriamycin Conjugates", Biochimica et Biophysica, Acta 1105:84-88 (1992).
Volpp et al., "Two Cytosolic Neutrophil Oxidase Components Absent in Autosomal Chronic Granulomatous Disease", Science 242:1294-1297 (1988).
Morre D., NADH Oxidase of Liver Plasma Membrane . . . Biochim et Biophys Acta 1057 (1991) 140-146.
Morre D., NADH Oxidase of Plasma Membranes J of Bioenergetics & Biomemebranes 23(4) 1991, pp. 469-489.
Bruno M., Stimulation of NADH Oxidase Activity Biochem J (1992) 284 625-628.
Morre D., Hormone and Growth Factor Stimulated . . . J of Bioener & Biomem 26(4) 1994 pp. 421-433.

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