Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-12-12
1999-11-02
Achutamurthy, Ponnathapura
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 435191, 43525233, 4353201, 536 231, 536 232, 536 235, 530350, C12Q 168, C07H 2104
Patent
active
059768045
ABSTRACT:
The invention provides a human NADH dehydrogenase subunit (HND-1) and polynucleotides which identify and encode HND-1. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HND-1.
REFERENCES:
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Hillier et al. EST, EMBL Accession No. N27384, NID g1141865, Dec. 30, 1995.
Cleeter, M.W.J. and C.I. Ragan, "The polypeptide compositon of the mitochondrial NADH: ubiquinone reductase complex from several mammalian species", Biochem. J., 230: 739-746 (1985).
Walker, J.E. et al., "Sequences of 20 Subunits of NADH: Ubiquinone Oxidoreductase from Bovine Heart Mitochondria", J. Mol. Biol., 226: 1051-1072 (1992).
Ali, S.T. et al., "Chromosomal Localization of the Human Gene Encoding the 51-kDa Subunit of Mitochondrial Complex I (NDUFV1) to 11q13", Genomics, 18: 435-439 (1993).
Singer, T.P. et al., "Deficiencies of NADH and succinate dehydrogenases in degenerative diseases and myophathies", Biochim. Biophys. Acta, 1271: 211-219 (1995).
Selvanayagam, P. And S. Rajaraman "Detection of Mitochondrial Genome Depletion by a Novel cDNA in Renal Cell Carcinoma", Lab. Invest., 74: 592-599 (1996).
Akman, S.A. et al., "DNA Base Modifications Induced in Isolated Human Chromatin by NADH Dehydrogenase-Catalyzed Reduction of Doxorubicin", Biochemistry, 31: 3500-3506 (1992).
Walker, J., (Direct Submission), GenBank Sequence Database (Accession X63224), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland, 20894, (GI 255; GI 256).
Guegler Karl J.
Hillman Jennifer L.
Achutamurthy Ponnathapura
Incyte Pharmaceuticals Inc.
Nashed Nashaat T.
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