Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving oxidoreductase
Patent
1994-04-21
1997-04-29
Paden, Carolyn
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving oxidoreductase
424 941, C12Q 128
Patent
active
056248130
ABSTRACT:
Chemiluminescence-based assays that detect or quantify determine NAD(P)-linked dehydrogenases and oxidoreductases, or the cofactors, or detect or quantify substrates, intermediates or products of reactions catalyzed by these enzymes by coupling the enzyme reactions to luminescence generating systems. The assays include the steps of reacting a peroxidase with the NAD(P)H produced in a reaction catalyzed by an oxidoreductase that requires NAD(P).sup.+ /NAD(P)H as a cofactor; and then adding a chemiluminescent moiety to produce chemiluminescence from which the analyte, such as an amino acid or sugar, the activity of the oxidoreductase or NAD(P).sup.+ /NAD(P) analyte, is determined. The assays are particularly useful for determining amino acids and sugars and, thus, are useful for quantitating amino acids and sugars in foods and for screening tissues body fluids, particularly blood, for diagnosing and managing metabolic defects in neonates and in adults.
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