Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-05-26
1996-11-12
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31415
Patent
active
055740570
ABSTRACT:
Naamidine A isolated from marine sponges is found to be selective in inhibiting the growth of tumor cells which are dependent upon epidermal growth factor for their growth, while showing acceptably low general cytotoxicity. Such selectivity was established through in vitro and in vivo comparative testing using tumor cells which over express EGF receptor cites. The in vivo tests used nude athymic mice that were implanted with squamous cells carcinoma.
REFERENCES:
patent: 4568665 (1986-02-01), Mitchell
patent: 4729996 (1988-03-01), Wright et al.
patent: 4737510 (1988-04-01), Rinehart, Jr.
patent: 4788190 (1988-11-01), Saksena et al.
patent: 4808590 (1989-02-01), Higa et al.
patent: 4866084 (1989-09-01), Gunasekera et al.
patent: 4908363 (1990-03-01), Klotzer et al.
patent: 4970226 (1990-11-01), Sun et al.
patent: 5064657 (1991-11-01), Jackson et al.
Carmely, et al., Naamines and Naamidines, Novel Imidazole Alkaloids From the Calcareous Sponge Leucetta Chagosensis, vol. 38, No. 26 Tetrahedron Letters, 3003-3006 (1987).
Carmely, et al., 2-Amino Imidazole Alkaloids From the Marine Sponge Leucetta Chagosensis, vol. 45, No. 7, Tetrahedron, 2193-2200 (1989).
Lyall, et al., Tyrophostins Inhibit Epidermal Growth Factor (EGF)-Receptor Tyrosine Kinase Activity in Living Cells and EGF-Stimulated Call Proliferation, vol. 264, No. 24, The Journal of Biological Chemistry, 14503-14509 (1989).
Copp Brent R.
Fairchild Craig R.
Ireland Chris M.
Goldberg Jerome D.
University of Utah Research Foundation
LandOfFree
Naamidine A extracted from sea sponges and methods for its use a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Naamidine A extracted from sea sponges and methods for its use a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Naamidine A extracted from sea sponges and methods for its use a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-562921