Naamidine A extracted from sea sponges and methods for its use a

Details Naamidine A extracted from sea sponges and methods for its use a Naamidine A extracted from sea sponges and methods for its use a

1994-05-26

1996-11-12

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31415

Patent

active

055740570

ABSTRACT:
Naamidine A isolated from marine sponges is found to be selective in inhibiting the growth of tumor cells which are dependent upon epidermal growth factor for their growth, while showing acceptably low general cytotoxicity. Such selectivity was established through in vitro and in vivo comparative testing using tumor cells which over express EGF receptor cites. The in vivo tests used nude athymic mice that were implanted with squamous cells carcinoma.

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Lyall, et al., Tyrophostins Inhibit Epidermal Growth Factor (EGF)-Receptor Tyrosine Kinase Activity in Living Cells and EGF-Stimulated Call Proliferation, vol. 264, No. 24, The Journal of Biological Chemistry, 14503-14509 (1989).

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