Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Blood
Patent
1992-11-30
1997-09-16
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Blood
424529, 424531, A61K 3516, A61K 3514
Patent
active
056678118
ABSTRACT:
The invention provides methods for obtaining substantially purified high and low molecular weight Na-K-ATPase inhibitor compounds having natriuretic and vasoconstrictive activity, antibodies reactive with the compounds and methods for their use in diagnostic and therapeutic applications to detect elevated or decreased amounts of the compounds in subjects having diseases associated with the presence or deficiency of these natriuretic compounds.
REFERENCES:
patent: 4321120 (1982-03-01), Nardi et al.
patent: 4665019 (1987-05-01), Hamlyn et al.
patent: 4727061 (1988-02-01), Kramer et al.
patent: 4746652 (1988-05-01), Buckalew, Jr. et al.
patent: 4780314 (1988-10-01), Graves
patent: 4780410 (1988-10-01), Matsuda et al.
patent: 4782014 (1988-11-01), Serban et al.
patent: 4940670 (1990-07-01), Rhodes
patent: 4940782 (1990-07-01), Rup et al.
patent: 4943533 (1990-07-01), Mendelsohn et al.
Morgan et al. (1985) J. Biol. Chem. 260(25):13595-13600.
Cloix et al. (1984) Experientia 40:1380-1382.
Hamlyn et al. (1989 Jun.) Hypertension 13 (6 pt.2): 681-689 (abstract only).
Weber et al. (1989, Oct.) Am. J. Hypertens. 2(10):754-61 (abstract only).
Gruber et al. (1978) Proc. Soc. Exp. Biol. Med. 159:463-467.
Haupert et al. (1984, Dec.) Am. J. Physiol. (6 Pt2) 247 F919-F924.
Gonick et al. (CV).
Gonick et al. (CH).
Veress et al. (1980) Clin. Su: 59:183-189.
Devynck et al. (1984) J. Physiol. 79:538-541.
Hamlyn et al. (1989, Jun.) Hypertension 13(6 Pt. 3):681-689. (abstract only).
Weber et al. (1989, Oct.) Am. J. Hypertens. 2(10):754-761. (abstract only).
Garner et al. (1984) Am. J. Physiol. 247(6 Pt. 2):F919-F924.
Kelly et al. (1985) J. Biol. Chem. 260(21):11396-11405.
Crabos et al. (1984) FEBS Lett. 176(1):223-228.
Roberts & Maurer, "Blood Pressure Levels of Persons 6-74 years", Vital health Stat 203:1 (1977).
Krishan, "Hypertension: Definition, Prevalence and Prognosis", in Spittel, Clinical Medicine, Harper & Row, Philadelphia, P.A. (1986).
Dahl, "Salt and Hypertension", Am. J. Clin. Nutr., 25:231 (1972).
Blaustein, "Role of a Natriuretic Factor in Essential Hypertension: An Hypothesis", Ann, Int. Med. 898:785-792 (1983).
Weber, et al., "Effects of a Human-Derived Sodium Transport Inhibitor on in vitro Vascular Reactivity", Am. J. Hypertension, 2(10):754-761 (1989).
Chiba, et al., "Vasoconstrictor Effects of Endogenous Digitalis-Like Factors Extracted from Urine of Hypertensive Patients", Heart Vessels, 3(3):129-134 (1987).
Mir, et al., "Calcium Retention and Increased Vascular Reactivity Caused by a Hypothalamic Sodium Transport Inhibitor", Clin. Sci., 75:197-202 (1988).
Haupert, "Regulation of Na.sup.+,-K.sup.+ -ATPase by the Endogenous Sodium Transport Inhibitor form Hypothalamus", Hypert, (Suppl. I) 10:I61-I66 (1987).
Buckalew and Nelson, "Natriuretic and Sodium Transport Inhibitory Activity in Plasma of Volume-Expanded Dogs", Kidney Int., 5:12-22 (1974).
Gonick, et al., "Circulating Inhibitor of Sodim-Potassium-Activated Adenosine Triphosphatase after Expansion of Extracellular Fluid Volume in Rats", Clin. Sci., 53:329-334 (1977).
Gonick, et al., "Regulation of Extracellular Volume: Critical Evaluation of Natriuretic Hormones", In Kruck & Thurau, Eds., Endocrine Regulation of Electrolyte Balance, Springer, Berlin, Heidelberg, New York, Tokyo, pp. 104-120.
Raghavan & Gonick, "Partial Purification and Characterization of Natriuretic Factor from Rat Kidney", Proc. Soc. Exp. Biol. Med., 164(1):101-104 (1980).
Gonick & Saldanha, "A Natriuretic Principle Derived from Kidney Tissue of Volume Expanded Rats", J. Clin. Invest., 56:247-255 (1975).
DeBold, "Heart Atria Granularity Effects of Changes in Water-Electrolyte Balance", Proc. Soc. Exp. Med. Biol., 161:508-511 (1979).
Atlas, et al., "Purification, Sequencing and Synthesis of Natriuretic Vasoactive Rat Atrial Peptide", Nature, 309:717-722 (1984).
Cogan, "Atrial Natriuretic Factor Can Increase Renal Solute Excretion Primarily by Raising Glomerular Filtration", Am. J. Physiol., 250:F710-714 (1986).
Soejima, et al., "Renal Response of Anesthetized Rats to Low-Dose infusion of Atrial Natriuretic Peptide", Am. J. Physiol., 255:R449-R455 (1988).
Flynn, et al., "The Amino Acid Sequence of an Atrial Peptide with Potent Diuretic and Natriuretic Properties", Biochem. Biophys. Res. Commun. 117:859-865 (1983).
Burgisser, et al., "Human Cardiac Plasma Concentrations of Atrial Natriuretic Peptide Quantified by Radioreceptor Assay", Biochem. Biophys. Res. Comm., 133:1201-1209 (1985).
Raine, et al., "Atrial Natriuretic Peptide and Atrial Pressure in Patients with Congestive Heart Failure", New Eng. J. Med. 315:534-537 (1986).
Gruber & Buckalew, "Further Characterization and Evidence for a Precursor in the Formation of Plasma Antinatriferic Factor", Proc. Soc. Exp. Biol. Med. 159:463-467 (1978).
Hamlyn, et al. "A Circulating Inhibitor of (Na.sup.+ +K.sup.+ ATPase) Associated with Essential Hypertension", Nature, 300:650-652 (1982).
Kelly, et al., "Characterization of Digitalis-Like Factors in Human Plasma. Interactions with Na-K-ATPase and Cross-Reactivity with Cardiac Glycoside-Specific Antibodies", J. Biol. Chem. 260:11396-11405 (1985).
Devynck et al., "Measurement of Digitalis-Like Compound in Plasma: Application in Studies of Essential Hypertension", Br. Med. J., 287:631-634 (1983).
Weiler, et al., "Observations on the Cascade" of Na-K-ATPase Inhibitory and Digoxin-Like-Immunoreactive Material in Human Urine: Possible Relevance to Essential Hypertension, Clin. Exp. Hypertension (A)7 & (5 and 6):809-836 (1985).
Kramer, et al., "Further Characterization of the Endogenous Natriuretic and Digoxin-Like Immunoreactivity Activities in Human Urine: Effect of Changes in Sodium Intake" Renal Physiol., 8:80-89 (1985).
Crabos, et al., "Measurement of Endogenous Na.sup.+, K.sup.+ -ATPase Inhibitors in Human Plasma and Urine Using High-Performance Liquid Chromatography", FEBS Letters, 176:223-228 (1984).
Klingmulter, et al., "Digoxin-Like Natriuretic Activity in the Urine of Salt Loaded Healthy Subjects", Klin. Wochenschr., 60(19)1249-1253 (1982).
Kelly, et al., "Identification of NaK-ATPAse Inhibitors in Human Plasma as Nonesterfied Fatty Acids and Lysophospholipids", J. Biol. Chem. 261:11704-11711 (1986).
Cloix, et al., "High-Yield Purification of a Urinary Na.sup.+ -Pump Inhibitor", Biochem. Biophys. Res. Commun., 131:1240 (1985).
Gruber, et al., "Further Characterization and Evidence for a Precursor in the Formation of Plasma Antinatriferic Factor" Proc. Soc. Exp. Biol. Med., 159:463-467 (1978).
Gruber, et al., "Endogenous Digitalis-Like Subtance in Plasma of Volume-Expanded Dogs", Nature, 287:743-745 (1980).
Sealey, et al., "Natriuretic Activity in Plasma and Urine of Salt-Loaded Man and Sheep", J. Clin. Invest., 48:221-224 (1969).
Clarkson, et al., "Two Natriuretic Substances in Extracts of Urine from Normal Man When Salt-Depleted and Salt-Loaded", Kidney Int., 10:381-394 (1976).
Morich & Garthoff, "Characteristic Changes of Plasma Proteins in the Dahl Hypertensive Rat Strain (DS) During the Development of Hypertension" Hypertension, 3:1249-1253 (1985).
John, et al., "Identification of a So-Far Not Characterized Human Serum Protein Associated with Essential Hypertension", Electrophoresis, 6:292-295 (1985).
Cloix, et al., "Plasma Protein Changes in Primary Hypertension in Humans and Rats", Hypertension, 5:128-134 (1983).
Van de Voorde, et al., "Isolation of a Plasma Protein Observed in Patients with Essential Hypertension", Biochem. Biophys. Res., 111:1015 (1983).
Weiler, et al., "Circulating High Molecular Weight Form of No-K-ATPase Inhibitor: Changes in Disease", Clin. Res., 34:90A (1986).
Veress, et al., "Characterization of the Natriuretic Activity in the Plasma of Hypervolaemic Rats", Clin. Sci., 59:183-189 (1980).
Pearce & Veress, "Concentration and Bioassay of a Natriuretic Factor in Plasma of Volume Expanded Rats", Can. J. Physiol. Pharmacol., 53:742-747 (1975).
Gruber, et al., "Evidence that Natriuretic Hormone is a Cascading Peptide Hormone System", In Lichardus, et al., Eds. Hormonal Regulation of Sodium Excretion, Elsevier/North-Holland, Amsterdam, pp.
Gonick Harvey C.
Khalil-Manesh Farhad
Weiler Elmar
Davenport Avis M.
The Regents of the University of California
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