N6-[(Imidazo[1,2-a]pyridin-3-yl)ethyl]adenosines, their 5'-urona

Details N6-[(Imidazo[1,2-a]pyridin-3-yl)ethyl]adenosines, their 5'-urona N6-[(Imidazo[1,2-a]pyridin-3-yl)ethyl]adenosines, their 5'-urona

1994-02-15

1995-10-17

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 2722, 536 2711, 536 2762, 536 2763, A61K 3170, C07H 19167

Patent

active

054591325

ABSTRACT:
The present invention relates to the derivatives of the formula ##STR1## and their addition salts, and to their use in therapeutics as analgesics, as antihypertensives and as drugs with antiproliferative properties.

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Daly, "Adenosine Receptors: Targets for Future Drugs," J. Med. Chem., 25(3), 197-207 (1982).
Jacobsen et al. "Adenosine Receptors: Pharmacology, Structure-Activity Relationships, and Therapeutic Potential," J. Med. Chem. 35(3), 407-422 (1992).
Daly et al., "Structure-Activity Relationships for N.sup.6 -Substituted Adenosines at a Brain at a Brain A.sub.1 -Adenosine Receptor with a Comparison to an A.sub.2 -Adenosine Receptor Regulating Coronary Blood Flow," Biochemical Pharmacology, 35(15), 2467-2481 (1986).
Levitzki, "Tyrphostins: Tyrosine Kinase Blockers as Novel Antiproliferative Agents and Dissectors of Signal Transduction," FASEB J., 6, 3277-3282 (1992).

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