Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1988-10-07
1993-01-12
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 2851, C07H 19073, C07H 2104, C07H 2102
Patent
active
051792001
ABSTRACT:
N4-(3-phenylproprionyl)-2'-deoxycytidine derivatives are disclosed having the following formula: ##STR1## wherein R.sup.1 is --CO--CH.sub.2 --CH.sub.2 --C.sub.6 H.sub.5, R.sup.5 is hydrogen, a trityl group or the group --CO--CH.sub.2 --CH.sub.2 --C.sub.6 H.sub.5, R.sup.6 is selected from the group consisting of hydrogen, --CO--CH.sub.2 --CH.sub.2 --C.sub.6 H.sub.5, ##STR2## and R.sup.7 is hydrogen or OH. These derivatives are useful in oligonucleotide synthesis because the 3-phenyl-proprionyl blocking group can be removed rapidly by ammonia.
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Molko Didier
Roget Andre
Schulhof Jean-Claude
Teoule Robert
Brown Johnnie R.
Commissariat a l''Energie Atomique
Kunz Gary L.
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