N3 alkylated benzimidazole derivatives as MEK inhibitors

Details N3 alkylated benzimidazole derivatives as MEK inhibitors N3 alkylated benzimidazole derivatives as MEK inhibitors

2011-08-23

2011-08-23

Stockton, Laura L. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S143000, C548S235000, C548S306100, C548S250000, C514S394000, C514S364000, C514S381000

Reexamination Certificate

active

08003805

ABSTRACT:
Disclosed are compounds of the Formula Iand pharmaceutically acceptable salts and prodrugs thereof, wherein W, R1, R2, R7, R8, R9and R10are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.

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