N-type calcium channel antagonists for the treatment of pain

Details N-type calcium channel antagonists for the treatment of pain N-type calcium channel antagonists for the treatment of pain

2006-06-13

2006-06-13

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S162000, C514S313000

Reexamination Certificate

active

07060834

ABSTRACT:
Compounds useful for the treatment of pain in accord with the following structural diagram,wherein A, R1, b, R4, R5, R6, R7and R8are any of a number of groups as defined in the specification, and pharmaceutical compositions and methods of treatment utilizing such compounds.

REFERENCES:
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patent: 4357333 (1982-11-01), Archibald et al.
patent: 636867 (1964-03-01), None
patent: WO 0064877 (2000-11-01), None
Jensen, CA 111:153665, abstract of Chemica Scripta 1988, vol. 28(4), pp. 435-437.
Ohta, CA 89:146868, abstract of Chemical & Pharmaceutical Bulletin, 1978, vol. 26(4), 1322-1325.
Pendersen, CA 87:22997, Abstract ofTetrahedron, 1977, vol. 33(2), pp217-220.
Falutta, CA 64:104047, abstract of Ric Sci, Rend, Sez A, 1965, vol. 8(4), pp 736-743.
E.B. Pedersen, “Synthesis of 2,4-bis(dimethylamino)quinolines by hmpt induced ring closure of anthranilates,” Tetrahedron Letters, p. 217-220, (Feb. 23, 1977).
Jorgen A. Jensen et al., “New One-step Synthesis of 2,4-bis(diakylamino)quinoines and 4,6-bis(dialkylamino)thieno[2,3-b]pyridines,” Chemica Scripta, vol. 28 (No. 4), p. 435-437, (Feb. 23, 1988).

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