N-type calcium channel antagonists for the treatment of pain

Details N-type calcium channel antagonists for the treatment of pain N-type calcium channel antagonists for the treatment of pain

2005-06-14

2005-06-14

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S152000, C514S313000, C514S159000, C514S160000

Reexamination Certificate

active

06906193

ABSTRACT:
Compounds useful for the treatment of pain in accord with the following structural diagram,wherein R1, R2, R3, R4and R5are any of a number of groups as defined in the specification, A and D are as defined in the specification, and pharmaceutical compositions and methods of treatment utilising such compounds.

REFERENCES:
patent: 5919776 (1999-07-01), Hagmann et al.
patent: 6576644 (2003-06-01), Bi et al.
patent: 0123146 (1984-10-01), None
patent: 2009155 (1984-06-01), None
patent: WO 9719929 (1997-06-01), None
Lucjan Strekowski et al., “Synthesis and Quantitative Structure-Activity Relationship Analysis of 2-(Aryl or Heteroaryl)quinolin-4-amines, a New Class of Anti-HIV-1 Agents,” J.Med. Chem., p. 1739-1746, (Apr. 9, 1991).
Danni L. Harris et al., “Determinants of recognition of ligands binding to benzodiazepine receptor/GABA A receptors initiating sedation,” European Journal of Pharmacology, (Aug. 9, 2000).
George Y. Sarkis et al., “Synthesis and Spectroscopic Properties of Some New N,N′-Disubstituted Thiorueas of Potential Biological Interest,” J. Heterocyclic Chem., p. 137-140, (Apr. 9, 1985).
Sigeru Torii et al., “Palladium-catalyzed facile access to 2-aryl-4-dialkylaminoquinolines,” Synlett, p. 513-514, (Jun. 9, 1992).
Sylviane Renault et Jean Renault (Chimie) et al., “Recherche sur les aminoquinoleines. XIV: alkylamino-4 quinoleines a longues chaines a activite amoebicide potentielle (2 memoire): influence de la position fe groupements alkyles nucleaires,” Eur. J. Med. Chem. Chimica Therapeutica, vol. 11 ( No. 6), p. 547-554, (Apr. 9, 1976).
Lucjan Strekowski et al., “Synthesis of Bis(2-arylquinolin-4-yl)amines by Lithium Bis(trimethylsilyl)amide-mediated Cyclization of Ketimines Derived from 2-(Trifluoromethyl)anilines and Aryl Methyl Ketones,” J. Org. Chem., p. 4193-4196, (Apr. 9, 1997).
Kiyoaki Katano et al., “Preparation of 4-aminoquinoline and 4-aminopentenopyridine derivatives and their use for improving brain disorders and heart function,” STN International, CAPLUS accession No. 1992:111483, document No. 117:111483.

Affiliated with

Also associated with

Rating

N-type calcium channel antagonists for the treatment of pain does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-type calcium channel antagonists for the treatment of pain, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-type calcium channel antagonists for the treatment of pain will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3462825