N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compos

Details N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compos N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compos

1975-09-25

1977-07-12

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 17, 536119, C07H 1520

Patent

active

040355667

ABSTRACT:
Esters of C.sub.4 -C.sub.10 saturated fatty acids with N-trifluoroacetyladriamycin are novel compounds. These compounds have the following structure: ##STR1## in which A is alkanoate having from 4 to 10 carbon atoms. Therapeutic compositions containing these compounds or the acetate or propionate of N-trifluoroacetyladriamycin are more effective than adriamycin in antitumor activity against murine P 388 and L 1210 leukemias and Ridgway osteogenic sarcoma in mice and at the same time significantly less toxic than adriamycin.

REFERENCES:
patent: 3803124 (1974-04-01), Arcamone et al.

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