N-trichloroacetyl-2-oxindole-1-carboxamides

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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544333, 544405, 546270, 546273, 548127, 548134, 548136, 548181, 548214, 548235, 548248, 548249, 548336, 548374, 548431, 548450, 548454, C07D40306, C07D491048, C07D491056, C07D49504

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050861867

ABSTRACT:
Preparation of 2-oxindole-1-carboxamides by reaction of 2-oxindoles with trichloracetyl isocyanate to produce novel N-trichloroacetyl-2-oxindole-1-carboxamides which are then hydrolyzed to 2-oxindole-1-carboxamides useful as analgesic and antiinflammatory agents and/or intermediates for such agents.

REFERENCES:
patent: 4658037 (1987-04-01), Kadin
patent: 4665194 (1987-05-01), Crawford
patent: 4952703 (1990-08-01), Kelly
Graf, Agnew, Chem. Internat. Edit 7, 172-182 (1968).

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