N-TRADD active site and uses thereof

Details N-TRADD active site and uses thereof N-TRADD active site and uses thereof

2004-07-20

2008-12-02

Borin, Michael (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Chemical analysis

C702S019000, C702S023000

Reexamination Certificate

active

07460961

ABSTRACT:
The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein (“N-TRADD”), as well as the identification and characterization of a C-TRAF2 binding active site of N-TRADD. Also provided for by the present invention are methods of utilizing the three dimensional structures for the design and selection of potent and selective inhibitors of TNF signaling pathways.

REFERENCES:
patent: 5674734 (1997-10-01), Leder et al.
patent: 5834228 (1998-11-01), Becker et al.
patent: 5856116 (1999-01-01), Wilson et al.
patent: 5939528 (1999-08-01), Clardy et al.
patent: 6322972 (2001-11-01), Lin et al.
patent: 2002/0094540 (2002-07-01), Tsao et al.
patent: WO 99/09148 (1999-02-01), None
Arch et al. “Tumor necrosis factor receptor-associated factors (TRAFs)—a family of adapter proteins that regulates life and death”Genes&Development12:2821-2830 (1988).
Baker et al. “Modulation of life and death by the TNF receptor superfamily”Oncogene17:3261-3270 (1998).
Boldin et al. “Self-association of the “Death Domains” of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects”J. of Biological Chemistry270(1):387-391 (1995).
Cao et al. “TRAF6 is a signal tranducer for interleukin-1”Nature383:443-446 (1996).
Cheng et al. “Involvement of CRAF1, a Relative of TRAF, in CD40 Signaling”Science267:1494-1498 (1995).
Chou et al. “Solution Structure of the RAIDD CARD and Model for CARD/CARD Interaction in Caspase-2 and Caspase-9 Recruitment”Cell94:171-180 (1988).
Day et al. “Solution Structure and mutagenesis of the capase recruitment domain (CARD) from Apaf-1”Cell Death and Differentiation6:1125-1132 (1999).
Duan et al. “RAIDD is a new ‘death’ adaptor molecule”Nature385:86-89 (1997).
Eberstadt et al. “NMR structure and mutagenesis of the FADD (Mort1) death-effector domain”Nature392:941-945 (1998).
Eck et al. “Crystallization of Trimeric Recombinant Human Tumor Necrosis Factor (Cachectin)”J. Biol. Chem. 263(26):12816-12819 (1988).
Farrell “Epstein-Barr virus immortalizing genes”Trends Microbio. 3:105-109 (1998).
Feinstein et al. “The death domain: a module shared by proteins with diverse cellular functions”Tibs20:342-344 (1995).
Grell et al. “TR60 and TR80 Tumor Necrosis Factor (TNF)-Receptors Can Independently Mediate Cytolysis”Lymphokine and Cytokine Res. 12:143-148 (1993).
Grell “Tumor Necrosis Factor (TNF) Receptors in Cellular Signaling of Soluble and Membrane-Expressed TNF”J. Inflamm. 47:8-17 (1995).
Hofmann et al. “The CARD domain: a new apoptotic signaling motif”TIBS22:155-156 (1997).
Hsu et al. “The TNF Receptor 1-Associated Protein TRADD Signals Cell Death and NF-κB Activation”Cell81:495-504 (1995).
Hsu et al. “TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex”Immunity4:387-396 (1996).
Hsu et al. “TRADD—TRAF2 and TRADD-FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways”Cell84:299-308 (1996).
Huang et al. “NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain”Nature384:638-641 (1996).
Jeong et al. “The Solution Structure of FADD Death Domain”J. Biol. Chem. 274(23):16337-16342 (1999).
Kelliher et al. “The Death Domain Kinase RIP Mediates the TNF-Induced NF—κB Signal”Immunity8:297-303 (1998).
Kieser et al. “LMP1 signal transduction differs substantially from TNF receptor I signaling in the molecular functions of TRADD and TRAF2”EMBO J. 18(9):2511-2521 (1999).
Liepinsh et al. “NMR structure of the death domain of the p75 neurotrophin receptor”EMBO J. 16(16):4999-5005 (1997).
McWhirter et al. “Crystallographic analysis of CD40 recognition and signaling by human TRAF2”Proc. Natl. Acad. Sci. USA96:8408-8413 (1999).
Nakano et al. “TRAF5, an Activator of NF-κB and Putative Signal Transducer for the Lymphotoxin-β Receptor”J. of Biol. Chem. 271(25):14661-14664 (1996).
Park et al. “Structural basis for self-association and receptor recognition of human TRAF2”Nature398:533-538 (1999).
Pullen et al. “CD40-Tumor Necrosis Factor Receptor-Associated Factor (TRAF) Interactions: Regulation of CD40 Signaling through Multiple TRAF Binding Sites and TRAF Hetero-Oligomerization”Biochemistry37:11836-11845 (1998).
Pullen et al. “CD40 Signaling through Tumor Necrosis Factor Receptor-associated Factors (TRAFs)”J. Biol. Chem. 274:14246-14254 (1999).
Qin et al. “Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1”Nature399:549-557 (1999).
Reinhard et al. “Tumor necrosis factor α-induced activation of c-jun N-terminal kinase is mediated by TRAF2”EMBO J. 16:1080-1092 (1997).
Rothe et al. “Tumor Necrosis Factor Receptors-Structure and Function”Immunol. Res.11:81-90 (1992).
Sato et al. “A novel member of the TRAF family of putative signal transducing protein binds to the cytosolic domain of the CD40”FEBS Letters358:113-118 (1995).
Sioud et al. “Design of Nuclease Resistant Protein Kinase Cα DNA Enzymes with Potential Therapeutic Application”J. Mol. Biol. 296:937-947 (2000).
Smith et al. “The TNF Receptor Superfamily of Cellular and Viral Proteins: Activation, Costimulation and Death”Cell76:959-962 (1994).
Song et al. “Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2”Proc. Natl. Acad. Sci.94:9792-9796 (1997).
Stanger et al. “RIP: A Novel Protein Containing a Death Domain That Interacts with Fas/APO-1 (CD95) in Yeast and Causes Cell Death”Cell81:513-523 (1995).
Sukits et al. “Solution Structure of the Tumor Necrosis Factor Receptor-1 Death Domain”J. Mol. Biol. 310:895-906 (2001).
Tartaglia et al. “Tumor Necrosis Factor's Cytotoxic Activity Is Signaled by the p55 TNF Receptor”Cell73:213-216 (1993).
Telliez et al. “Mutational Analysis and NMR studies of the Death Domain of the Tumor Necrosis Factor Receptor-1”J. Mol. Biol. 300:1323-1333 (2000).
Vandevoorde et al. “Induced Expression of Trimerized Intracellular Domains of the Human Tumor Necrosis Factor (TNF) p55 Receptor Elicits TNF Effects”J. Cell Biol. 137(7):1627-1638 (1997).
Xiao et al. “Three-Dimensional Structure of a Complex between the Death Domains of Pelle and Tube”Cell99:545-555 (1999).
Yuan “Transducing signals of life and death”Curr. Opin. Cell Biol. 9:247-251 (1997).
Zhou et al. “Solution Structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A Structural basis for specific adaptor/caspase interaction”Proc. Natl. Acad. Sci. USA96:11265-11270 (1999).

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