N-terminally chemically modified protein compositions and method

Details N-terminally chemically modified protein compositions and method N-terminally chemically modified protein compositions and method

1997-06-20

1999-11-16

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

424 851, 424 855, 424 856, 424 857, 514 2, 514 12, 514 21, 530351, 530402, 530406, A61K 3821, C07K 1452, C07K 1708

Patent

active

059852658

ABSTRACT:
Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.

REFERENCES:
patent: 4002531 (1977-01-01), Royer
patent: 4766106 (1988-08-01), Katre et al.
patent: 5252714 (1993-10-01), Harris et al.
patent: 5372808 (1994-12-01), Blatt et al.
patent: 5382657 (1995-01-01), Karasiewicz et al.

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