Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1994-10-12
1998-10-20
Achutamurthy, Ponnathapura
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530350, 530402, 530410, A61K 3818, C07K 100
Patent
active
058247840
ABSTRACT:
Provided herein are methods and compositions relating to the attachment of water soluble polymers to proteins. Provided are novel methods for N-terminally modifying proteins or analogs thereof, and resultant compositions, including novel N-terminally chemically modified G-CSF compositions and related methods of preparation. Also provided is chemically modified consensus interferon.
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DePrince Randolph B.
Farrar Christine E.
Gabriel Nancy E.
Kinstler Olaf B.
Achutamurthy Ponnathapura
Amgen Inc.
Odre Steven M.
Pessin Karol M.
Winter Robert B.
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