N-terminal CTP extended pharmaceutical peptides and proteins

Details N-terminal CTP extended pharmaceutical peptides and proteins N-terminal CTP extended pharmaceutical peptides and proteins

1995-06-07

1998-06-02

Spector, Lorraine M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 6952, 435 695, 4351723, 435325, 4353651, 4352523, 4353201, 424 851, 424 852, 4241921, 530350, 530351, 530398, 536 234, 930110, 930141, 935 10, C12N 1562, C12N 1519, C12N 1524, A61K 3824

Patent

active

057598185

ABSTRACT:
"Partial" and "complete" CTP units are used to modify biologically active proteins and peptides at the aminoterminus to alter their clearance patterns. "Complete" CTP units have the amino acid sequence found at positions 112-118 to position 145 of the .beta.-subunit of human chorionic gonadotropin; "partial" CTP units are missing at least one amino acid in the region of position 118-145 inclusive. Variants of these CTP units contain 1-5 conservative amino acid substitutions which do not destroy activity. Suitable peptides or proteins which may be modified in this manner include various hormones and cytokines.

REFERENCES:
patent: 4400316 (1983-08-01), Katsurgi
patent: 4654324 (1987-03-01), Chance et al.
patent: 4923805 (1990-05-01), Reddy et al.
patent: 4959455 (1990-09-01), Clark et al.
patent: 5177193 (1993-01-01), Boime et al.
patent: 5216126 (1993-06-01), Cox et al.
patent: 5217881 (1993-06-01), Park
patent: 5338835 (1994-08-01), Boime
Davis, C.G. et al., J. Biol. Chem., 261(6):2828 (1986).
Goochee, C.F. et al., Biotechnology, (1991) 9:1347.
Kessler, M.J. et al., J. Biol. Chem. 254(16):7909 (1979).
LaPolt, P.S. et al., "Enhanced Stimulation of Follicle Maturation and Ovulatory Potential by Long Acting Follicle-Stimulating Hormone Agonists with Extended Carboxyl-Terminal Peptides," Endocrinology 131:2514-2520 (1992).
Boime, I. et al. "Structure-function studies of gonadotropins using site-directed mutagenesis and gene transfer: design of a long-acting follitropin agonist," Chemical Abstracts 123:127 Abstract 123:1188n 1995.
Fares, F. A. et al. "Design of a long-acting follitropin agonist by fusing the C-terminal sequence of the chorionic gonadotropin beta subunit to the follitropin subunit" Proc. Natl. Acad. Sci. USA 89(10):4304-4308 May 1992.

Affiliated with

Also associated with

Rating

N-terminal CTP extended pharmaceutical peptides and proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-terminal CTP extended pharmaceutical peptides and proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-terminal CTP extended pharmaceutical peptides and proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1458556