N-t-butyloxycarbonyl-3-cyclohexyl-L-alanine methyl ester in crys

Details N-t-butyloxycarbonyl-3-cyclohexyl-L-alanine methyl ester in crys N-t-butyloxycarbonyl-3-cyclohexyl-L-alanine methyl ester in crys

1992-08-03

1994-02-15

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C26100

Patent

active

052868974

ABSTRACT:
N-t-butyloxycarbonyl-3-cyclohexyl-L-alanine methyl ester, previously known only as an oil, is provided in crystalline form. By addition of an organic solvent, such as methanol and/or n-hexane, to the ester in the form of an oil and cooling, crystals may be obtained. Alternatively, the ester in oily form may be seeded with a crystal produced previously. The crystalline material is of higher purity than the previously known oils, and is more useful than the oils as an intermediate in the pharmaceutical industry.

REFERENCES:
patent: 4948913 (1990-08-01), Kleinman et al.
patent: 5010057 (1991-04-01), Henning
Boger, J. Med. Chem., 28, pp. 1779-1790 (1985).
Ault, "Techniques and Experiments for Organic Chemistry, " 4th Ed. pp. 44-49 & 56-57 (1983).
J. Boger et al., Renin Inhibitors. Syntheses of Subnanomolar, Competitive Transition-State Analog Inhibitors Containing A Novel Analog of Statine, Chemical Abstracts, vol. 103, No. 23, Dec. 9, 1985, Columbus, Ohio, pp. 1 & 713, 196406z.

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