N.sup.9 alkyl or aralkyl derivatives of 7, 8-disubstituted guani

Details N.sup.9 alkyl or aralkyl derivatives of 7, 8-disubstituted guani N.sup.9 alkyl or aralkyl derivatives of 7, 8-disubstituted guani

1996-08-27

1998-07-28

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544276, C07D47318, A61K 3152

Patent

active

057863598

ABSTRACT:
Immunostimulating 7,8-disubstituted guanine derivatives that also contain a 9-alkyl, 9-alkoxy or 9-aralkyl substituent are disclosed whose structures are represented by Formula I ##STR1## wherein X is O or S; R.sup.1 is a hydrocarbyl or substituted hydrocarbyl group having a length of about one to about seven carbon atoms; R.sup.2 is a hydrocarbyl or hydroxyl- or ether-substituted hydrocarbyl group having a length of about four to about ten carbon atoms; and the pharmaceutically acceptable base addition salts thereof. Also disclosed are compositions containing an immunostimulating guanine derivative and processes for using the same.

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Madre, Chem Abs 118, 192162d (1993).
Michael, J Med Chem 36, 3431 (Oct. 1993).
Reitz, J. Med. Chem 37, 3561 (1994).
Goodman, J. Immunol. 141, 2394 (1988).
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