Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-04-21
1999-11-02
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 81, 530345, 530352, 530409, 544244, 546 23, A61K 31675, A61K 3802, C07F 938, C07K 200
Patent
active
059770619
ABSTRACT:
Novel PMP, PME and HPMP and related compounds containing N-6 substituted 2,6-diaminopurine and adenine bases are provided. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame retardants, diagnostic reagents and therapeutics, including antivirals. Of particular note are compounds otherwise not known to possess anti-DNA viral activity that become potent inhibitors of DNA viruses upon substitution of the N-6 site, thereby providing a novel and unexpected and surprising use for such compounds.
REFERENCES:
patent: 4659825 (1987-04-01), Holy et al.
patent: 4724233 (1988-02-01), De Clercq et al.
patent: 4808716 (1989-02-01), Holy et al.
patent: 5142051 (1992-08-01), Holy et al.
patent: 5208221 (1993-05-01), Kim et al.
patent: 5302585 (1994-04-01), Yu et al.
patent: 5352786 (1994-10-01), Jindrich et al.
patent: 5356866 (1994-10-01), Arai et al.
patent: 5356886 (1994-10-01), Harnden
patent: 5514798 (1996-05-01), Bischofberger et al.
patent: 5591851 (1997-01-01), Alexander
Ching et al., "Nonclinical toxicology and in vitro Toxicity Studies with the Novel Anti-HIV Agent (1S,4R)-4-[2-Amino-6-(Cyclopropylamino)-9H-Purin-9-YL]-2-Cyclopentene-1-Me thanol (1592U89) Succinate," Presentations @ the 34th Interscience Conf. on Antimicrobial Agents & Chemotherapy, Orlando, Florida Abstract # 188 (Oct. 4-7, 1994).
Cihlar et al., "Transport of 9-(2-Phosphonomethoxyethyl)Adenine across Plasma Membrane of HeLa S3 Cells Is Protein Mediated," Antimicro AG & Chemo 39(1):117-124 (1995).
Colla, et al., "Synthesis of aliphatic nucleoside analogues with potential antiviral activity," Eur J Med Chem 17:569-576 (1982).
Daluge et al., "1592U89 Succinate--A Novel Carbocylic Nucleoside Analog With Potent, Selective Anti-HIV Activity," Presentations @ the 34th Interscience Conf. on Antimicrobial Agents & Chemotherapy, Orlando, Florida Abstract # 16 (Oct. 4-7, 1994).
De Clercq et al., "Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines," Antiviral Res 8:261-272 (1987).
Faletto et al., "Unique Intracellular Activation of a New Anti-HIV Agent (1S,4R)-4-[2-Amino-6-(Cyclopropylamino)-9H-Purin-9-YL]-2-Cyclopentene-1-Me thanol (1592U89) in the Human T-Lymphoblastoid Cell Line CEM-T4," Presentations @ the 34th Interscience Conf. on Antimicrobial Agents & Chemotherapy, Orlando, Florida Abstract # 184 (Oct. 4-7, 1994).
Good et al., "Disposition in Monkeys and Mice of (1S,R4)-4-[2-Amino-6-(Cyclopropylamino)-9H-Purin-9-YL)-2-Cyclopentene-1-Me thanol (1592U89) Succinate, A Potent Inhibitor of HIV," Presentations @ the 34th Interscience Conf. on Antimicrobial Agents & Chemotherapy, Orlando, Florida Abstract # 186 (Oct. 4-7, 1994).
Holy et al., "Antiviral Acyclic Nucleotide Analogues," Antibiotics and Antiviral Compounds 455-462 (1993).
Schaeffer, et al, "Enzyme Inhibitors. VIII. Studies on the Mode of Binding of Some 6-Substituted 9-(Hydroxyalkyl)purines to Adenosine Deaminase," J Med Chem 8(4):502-506 (1965).
Tisdale et al., "Anti-HIV Activity of (1S,4R)-4-[2-Amino-6-(Cyclopropylamino)-9H-Purin-9-YL]-2Cyclopentene-1-Met hanol (1592U89)," Presentations @ the 34th Interscience Conf. on Antimicrobial Agents & Chemotherapy, Orlando, Florida Abstract # 182 (Oct. 4-7, 1994).
Balzarini et al., "Differential Antiherpesvirus and Antiretrovirus Effects of the (S) and (R) Enantiomers of Acyclic Nucleoside Phosphonates: Potent and Selective In Vitro and In Vivo Antiretrovirus Activities of (R)-9-(2-Phosphonomethoxypropyl)-2,6-Diaminopurine," Antimicrobial Agents and Chemotherapy, 37(2):332-338 (1993).
Dvorakova et al., "Synthesis and Antiviral Activity of Acyclic Nucleoside and Nucleotide Derivatives of 8-Azaadenine," Collect. Czech. Chem. Commun., 58:253-255 (1993).
Dvorakova et al., "Synthesis and Biological Effects of 9-(3-Hydroxy-2-Phosphonomethoxypropyl)Derivatives of Deazapurine Bases," Collect. Czech. Chem. Commun., 58:1403-1418 (1993).
Holy et al., "Phosphonylmethyl Ethers of Nucleosides and Their Acyclic Analogues," Am. Chem. Soc., Nucleotide Analogues, Chpt. 4, pp. 51-71 (1989).
Naesens et al., "HPMPC (Cidofovir), PMEA (adefovir) and Related Acyclic Nucleoside Phosphonate Analogues: A Review of their Pharmacology and Clinical Potential in the Treatment of Viral Infections," Antiviral Chem. & Chemotherapy, 8(1):1-23 (1997).
De Clercq Erik Desire Alice
Holy Antonin
Hensley Max D.
Institute of Organic Chemistry and Biochemistry of the Academy o
Rega Stichting v.z.w.
Russel Jeffrey E.
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