Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1990-08-23
1993-09-21
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 2613, A61K 3170, C07H 19213
Patent
active
052469220
ABSTRACT:
The present invention relates to a N.sup.6,N.sup.6 -disubstituted-cyclic adenosine-3',5'-monophosphate represented by the formula ##STR1## wherein R represents a linear alkyl group having 3 or more carbon atoms or a branched alkyl group having 4 or more carbon atoms, an aralkyl group or an alkenyl group; A.sup..sym. represents a hydrogen ion, an alkali metal ion, an alkaline earth metal ion, an ammonium ion or an organoammonium ion, or a salt thereof, and a cardiac composition comprising it as an effective component, and further includes a process for preparing a compound represented by the formula ##STR2## wherein R.sub.1 represents an alkyl group, an aralkyl group or an alkenyl group and A.sup..sym. has the same meanings as defined above, or a salt thereof, characterized in that a 2'-O-protected-cyclic adenosine-3',5'-monophosphate represented by the formula ##STR3## wherein Y represents a protecting group and A.sup..sym. has the same meanings as defined above, or a salt thereof is reacted with an organic halide represented by the formula
REFERENCES:
patent: 3712885 (1973-01-01), Weimann et a.
patent: 3856776 (1974-12-01), Cehovic et al.
patent: 4044123 (1977-08-01), Daniels et al.
patent: 4058659 (1977-11-01), Robins et al.
patent: 4458067 (1984-07-01), Yamaji et al.
patent: 4567254 (1986-01-01), Kataoka et al.
patent: 4751293 (1988-06-01), Kataoka et al.
patent: 4902677 (1990-02-01), Imai et al.
Kataoka et al., Nucleic Acids Symp. Ser. 1989, 21:1-2.
Rall et al., "The Potentiation of Cardiac Inotropic Responses to Norepinephrine by Theophylline", J. Pharmacol. Exptl. Therap., vol. 139, 269 (1963).
Meyer et al., "Synthesis and Biological Activity of Several 6-Substituted 9-.beta.-D-Ribofuranosylpurine 3',5'-Cyclic Phosphates", Biochemistry, vol. 11, No. 14 (1972).
Morrison et al., Organic Chemistry, pp. 740-741 (ed Ed., 1973).
Uesugi et al., "Synthesis and Properties of the Dinucleoside Monophosphate of Adenine 8-Thiocyclonucleoside", Journ. Amer. Chem. Soc., 94:15 (1972) pp. 5480-5486.
Imai et al., "Effects of Cyclic AMP and Dibutyryl Cyclic AMP on the Heart and Coronary Circulation", Japan. J. Pharmacol., 24, 499-510 (1974).
Boswell et al., "Syntheses of 6,8-Disubstituted-9-.beta.-D-Ribofuranosylpurine 3',5'-cyclic Phosphates", J. Heterocyclic Chem., 12, 1, (1975).
Yamaji et al., "Inotropic and Chronotropic Actions of 2-Substituted and 8-Substituted Derivatives of Adenosine 3',5'-Cyclic Monophosphate", Chem. Pharm. Bull., 28(6) 16 83-1687 (1980).
Miller et al., "Synthesis and Enzymatic and Inotropic Activity of Some New 8-Substituted and 6,8-Disubstituted Derivatives of Adenosine Cyclic 3',5'-Monophosphate", J. Med. Chem., 23, 242-251 (1980).
Ogreid et al., "Activation of Protein Kinase Isozymes by Cyclic Nucleotide Analogs Used Singly or in Combination", Eur. J. Biochem., 150, 219-227 (1985).
Matsui et al., "Efficacy of Dibutyrl Cyclic AMP in Heart Failure Unresponsive to Catecholamines", Clinical Therapeutics, vol. 9, No. 5, 488-499 (1987).
Kataoka et al., Nucleic Acids Research Symposium Series, 21, 1-2 (1989); cited in Chem. Abstr., 112:91322b (1990).
Boswell et al., J. Heterocyclic Chem., 12(1), 1-9 (1975).
Ogreid et al., Eur. J. Biochem., 181, 19-31 (1989).
Doskeland et al., Biochemistry, 22(5), 1094-1101 (1983).
Tagliaferri et al., J. Biol. Chem., 263(1), 409-416 (1988).
Baumann et al., Biochim, Biophys. Acta, 871, 199-206 (1986).
Ogreid et al., J. Biol. Chem., 258(2), 1041-1049 (1983).
van Boom et al., J. Chem. Soc. Chem. Comm., 1974, 618-619.
March et al., "Advanced Organic Chemistry: Reactions, Mechanisms, and Structure," McGraw-Hill Book Company, New York, N.Y., 1968, see pp. 331-332, particularly, p. 331, lines from the bottom.
Kochetkov et al., "Organic Chemistry of Nucleic Acids: Part B," Plenum Press, New York, N.Y., 1972, p. 453, top paragraph.
Ogilvie et al., Nucleic Acids Research, Symposium Series No. 7, 147-150 (1980).
Imai et al., "Effects of Cyclic AMP and Dibutyryl Cyclic AMP on the Heart and Coronary Circulation," Japan J. Pharmacol., 24, 499-510 (1974).
Imai Shoichi
Kataoka Shigehiro
Kato Motohiko
Yamaji Nobuyuki
Brown Johnnie R.
Crane L. Eric
Kikkoman Corporation
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