N.sup.6 -[3-(1-substituted)indolylethyl] adenosine 5'-carboxamid

Details N.sup.6 -[3-(1-substituted)indolylethyl] adenosine 5'-carboxamid N.sup.6 -[3-(1-substituted)indolylethyl] adenosine 5'-carboxamid

1992-02-07

1993-07-20

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2722, C07H 19167

Patent

active

052295052

ABSTRACT:
The present invention relates to the derivatives of the formula ##STR1## and their addition salts, and to their use in therapeutics, especially in the central nervous system as analgesics, anticonvulsants, antiepileptics, anxiolytics, antidepressants and neuroprotectors, and in the cardiovascular system as antiarrhythmics, antihypertensives and platelet aggregation inhibitors.

REFERENCES:
patent: 4167565 (1979-09-01), Stein et al.
patent: 5023244 (1991-06-01), Goto et al.
Francis et al., "Highly Selective Adenosine A.sub.2 Receptor Agonists in a Series of N-alkylated 2-Aminoadenosines," J. Med. Chem., 34, 2570-2579 (1991).
Schillinger et al., "Metabolic Effects of N.sup.6 -Substituted Adenosines in Rats," Biochemical Pharmacology, 23, 2283-2289 (1974).
Journal of Medicinal Chemistry, vol. 16, No. 4, Wash., US, pp. 358-364, Kiyomi Kikugawa et al.

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