N.sup.4 -Acylcytosine arabinoside compositions

Details N.sup.4 -Acylcytosine arabinoside compositions N.sup.4 -Acylcytosine arabinoside compositions

1980-07-16

1982-05-18

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugate includes potentiator; or composition comprising...

424180, 536 23, A61K 3170, C07H 1908, A61K 31705

Patent

active

043305342

ABSTRACT:
A N.sup.4 -acylcytosine arabinoside preparation which consists essentially of (a) a liposome of lecithin and (b) a N.sup.4 -acylcytosine arabinoside having a C.sub.6-18 aliphatic acyl group and being encapsulated in the liposome.

REFERENCES:
patent: 3991045 (1976-11-01), Ishida et al.
patent: 4055716 (1977-10-01), Ishida et al.
Rahman et al., "Chem. Abst.", vol. 89, 1978, P 94,958f.
Aoshima et al., "Cancer Research", vol. 36, pp. 2726-2732, Aug. 1976.
Aoshima et al., "Cancer Research", vol. 37, pp. 2481-2486, Aug. 1977.
Juliano et al., "Biochemical Pharmacology", vol. 27, pp. 21-27, 1978.

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