N.sup.2 -(Substituted)carboxymethyl-N.sup.6 -(substituted)-lysyl

Details N.sup.2 -(Substituted)carboxymethyl-N.sup.6 -(substituted)-lysyl N.sup.2 -(Substituted)carboxymethyl-N.sup.6 -(substituted)-lysyl

1983-02-18

1985-11-26

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

2601125R, A61K 3700, C07C10352

Patent

active

045555036

ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sup.2 is ##STR2## wherein k is 2 to 5; R.sup.3 is hydrogen; loweralkyl and substituted loweralkyl where the substituents are carboxy, hydroxy, and amino; or aralkyl, substituted aralkyl, heteroaralkyl, and substituted heteroaralkyl where the aryl and heteroaryl substituents are carboxy, hydroxy, and amino; and C is COOR; CONH.sub.2 ; or CH.sub.2 OH; and a pharmaceutically acceptable salt thereof; are inhibitors of angiotensin I converting enzyme useful as antihypertensive agents.

REFERENCES:
patent: 4113715 (1978-09-01), Ondetti et al.
patent: 4129571 (1978-12-01), Ondetti et al.
patent: 4154960 (1979-05-01), Ondetti et al.

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