N.sup.2 -Naphthalenesulfonyl-L-arginine derivatives, and the pha

Details N.sup.2 -Naphthalenesulfonyl-L-arginine derivatives, and the pha N.sup.2 -Naphthalenesulfonyl-L-arginine derivatives, and the pha

1977-01-19

1978-01-17

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

260112SR, 260239A, 260239B, 260239E, 260239BF, 260288R, 260288D, 26029362, 2603261, 26032611R, 26032633, 2603265SF, 2603472, 26050112, 26050114, 260518R, 260556B, 424177, 424244, 424258, 424274, 424309, 424311, 424319, 424321, 560 10, 560251, A61K 31445, C07D21116

Patent

active

040693295

ABSTRACT:
N.sup.2 -naphthalenesulfonyl-L-arginine esters and amides having the formula ##STR1## or the acid addition salts thereof with a pharmaceutically acceptable acid, wherein R is selected from the class consisting of (1) alkoxy, alkenyloxy, cycloalkoxy and halogenated alkoxy, aralkyloxy, and alkoxy substituted with an alkoxy group; ##STR2## wherein R.sub.1 and R.sub.2 are members selected from the class consisting of hydrogen, alkyl, aryl, alkenyl and cycloalkyl, and aralkyl and cycloalkylalkyl, and substituted alkyl, said substituent being selected from the class consisting of alkoxy, alkoxycarbonyl, acyl, acyloxy, arylcarbamoyl and N,N-polymethylenecarbamoyl, and carboxy; and ##STR3## wherein Z is a divalent group containing up to 10 carbon atoms, which consists of more than one group selected from the class consisting of methylene, monosubstituted methylene; and disubstituted methylene, and which may further contain at least one member selected from the class consisting of oxy-O-, thio --S--, cycloalkylene, imino, alkyl-substituted imino, acyl-substituted imino, and phenylene, which may be arranged in any order and complete the ##STR4## ring together with the said methylene, monosubstituted methylene or disubstituted methylene, and R' is a member selected from the class consisting of 1-naphthyl substituted 2-, 3-, 4-, 6-, 7- or 8-dialkylamino, respectively, containing not more than 20 carbon atoms, and 1-naphthyl substituted with 5-dialkylamino containing 3 - 20 carbon atoms, 2-naphthyl substituted dialkylamino containing not more than 20 carbon atoms.

REFERENCES:
patent: 3622614 (1971-11-01), Nicolaides et al.
patent: 3978045 (1976-08-01), Okamoto et al.

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