Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1998-02-17
2000-05-09
Barts, Samuel
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
564313, A61R 31045
Patent
active
060605162
ABSTRACT:
The present invention is directed to novel N.sup.1 -propargylhydrazines, N.sup.2 -propargylhydrazines and their salts in pharmaceutical compositions. The compounds according to the present invention have at least one of the following activities: monoamine oxidase-A inhibiting, monoamine oxidase-B inhibiting, anti-depressant, anti-anxiety and neuroprotectant activities. These compounds are useful as monoamine oxidase inhibitors and should be useful for the treatment of depression, anxiety and of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.
REFERENCES:
patent: 3213138 (1965-10-01), Biel et al.
patent: 3359316 (1967-12-01), Biel et al.
Chem Abstracts 191:603466; rn 61944-48-7; Darbinyan et al, 1981.
Bielstein Abstract of GMELIN registry No. 959297; Baum, Marc M.; Edward H.; J. Chem Soc., Perkin Trans. 1; (1993) 2513-2520; JCPRB4; English; Jun., 1993.
Baker Glen
Coutts Ronald
Pang Peter K. T.
Shan Jacqueline
Sloley Duff
Barts Samuel
CV Technologies Inc.
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