N.sup.1 -propargylhydrazines, N.sup.2 -propargylhydrazines and t

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai

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564313, A61R 31045

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active

060605162

ABSTRACT:
The present invention is directed to novel N.sup.1 -propargylhydrazines, N.sup.2 -propargylhydrazines and their salts in pharmaceutical compositions. The compounds according to the present invention have at least one of the following activities: monoamine oxidase-A inhibiting, monoamine oxidase-B inhibiting, anti-depressant, anti-anxiety and neuroprotectant activities. These compounds are useful as monoamine oxidase inhibitors and should be useful for the treatment of depression, anxiety and of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.

REFERENCES:
patent: 3213138 (1965-10-01), Biel et al.
patent: 3359316 (1967-12-01), Biel et al.
Chem Abstracts 191:603466; rn 61944-48-7; Darbinyan et al, 1981.
Bielstein Abstract of GMELIN registry No. 959297; Baum, Marc M.; Edward H.; J. Chem Soc., Perkin Trans. 1; (1993) 2513-2520; JCPRB4; English; Jun., 1993.

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