N-substituted thiolactams

Details N-substituted thiolactams N-substituted thiolactams

1991-08-16

1993-06-08

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

546243, 548543, C07D22306, C07D21182, C07D20722

Patent

active

052181138

ABSTRACT:
This invention provides compositions comprising a physiologically-active agent and a compound having the structural formula ##STR1## wherein X may represent sulfur or two hydrogen atoms; R' is H or a lower alkyl group having 1-4 carbon atoms; m is 2-6; n is 0-18 and R is --CH.sub.3, ##STR2## wherein R'' is H or halogen, in an amount effective to enhance the penetration of the physiologically-active agent through the skin or other membrane of the body of an animal.

REFERENCES:
patent: 4415563 (1983-11-01), Rajadhyaksha
patent: 4557934 (1985-12-01), Cooper
patent: 4992422 (1991-02-01), Minaskanian et al.
Chemical Abstracts vol. 84, Item 175139 p, (1976) (abstracting Japanese Kokai 76 01,634 published Jan. 8, 1976).

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