N-substituted thiazolyl derivatives of oxy-imino-substituted cep

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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544 22, 544 27, 544 28, 542416, A61K 3154, C07D50100

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active

043584489

ABSTRACT:
Derivatives of N-substituted thiazolyl oxy-imino-substituted cephalosporins, such as, for instance, the compound 7.beta.-[2-(2-imino-3-hydroxy-4-thiazolinyl)-2-methoxy-imino-acetamino]-3- [(tetrazolo[1,5-b]pyridazin-6-yl)-thiomethyl]-3-cephem-4-carboxylic acid, are disclosed. The disclosed compounds have high anti-bacterial activity against Gram-positive and Gram-negative bacteria normally susceptible to cephalosporins.

REFERENCES:
Derwent Farmdoc 70716Y-Abstract of Belgian Pat. 853,073 (2/77).
Derwent Farmdoc 76253A-Abstract of Belgian Pat. 866,038 (10/78).
Derwent Farmdoc 66853Y-Abstract of Belgian Pat. 852,427 (9/77).
Derwent Farmdoc 74147Y-Abstract of Belgian Pat. 853,545 (10/77).
Derwent Farmdoc 00060A-Abstract of Belgian Pat. 856,045 (2/77).
Derwent Farmdoc 46081W-Abstract of Belgian Pat. 823,861 (6/75).
Derwent Farmdoc 37977B-Abstract of Japan Kokai 44695/79 (1/78).
Derwent Farmdoc 79405B-Abstract of European Pat. 4956 (10/78).
Derwent Farmdoc 50298X-Abstract of German Offenlegungsschrift 2,556,736 (6/76).

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