Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-10-04
2005-10-04
Huang, Evelyn Mei (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S233200, C514S303000, C546S121000, C546S112000, C544S127000
Reexamination Certificate
active
06951867
ABSTRACT:
This invention provides a compound of the formula (I):or a pharmaceutically acceptable salt, amide or ester thereof, wherein R1represents a hydrogen atom or a halogen atom; R2represents a hydrogen atom, etc.; R3represents an alkyl group having from 1 to 10 carbon atoms; said alkyl group of R3is substituted by at least one substituent selected from the group consisting of substituents α; said substituents α is aryl, hydroxy, oxo, etc.; said aryl having 6 to 10 carbon atoms; said aryl is unsubstituted or substituted by at least one alkyl group having from 1 to 6 carbon atoms; said heterocyclic and the heterocyclic moiety of said heterocycliccarbonyl, both of substituents α, are 5- to 10-membered cyclic groups containing from 1 to 4 heteroatoms selected from the group consisting of nitrogen atoms, oxygen atoms and sulfur atomsThese compounds have 5-HT4receptor binding activity, and thus are useful for the treatment of gastroesophageal reflux disease, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome or the like in mammalian, especially humans. This invention also provides a pharmaceutical composition comprising the above compound.
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Katsu Yasuhiro
Kon-I Kana
Morita Mikio
Noguchi Hirohide
Uchida Chikara
Benson Gregg C.
Forman Frank W.
Huang Evelyn Mei
Pfizer Inc.
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