N-substituted piperidines as PDE4 inhibitors

Details N-substituted piperidines as PDE4 inhibitors N-substituted piperidines as PDE4 inhibitors

1997-09-19

1999-07-06

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514249, 514311, 514318, 514330, 544353, 546152, 546193, 546210, 546221, A61K 31445, C07D40106

Patent

active

059198010

ABSTRACT:
New N-substituted cyclic amines of formula: ##STR1## wherein: X, R.sub.1, R.sub.2 and R are as defined in the description, their optical and geometric isomers and physiologically tolerable salts thereof. The compounds of the invention are powerful PDE4 inhibitors and can be used therapeutically.

REFERENCES:
patent: 5434158 (1995-07-01), Shah
patent: 5459151 (1995-10-01), Lombardo
Burger "A guide to the chemical basis of drug design" Wiley Interscien Pub. p. 15, 1983.
Lowe et al. "Preparation of piperazine and piperidine derivatives . . . " CA 128:180426, 1998.

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