N-(substituted phenyl and benzyl)abietamides

Details N-(substituted phenyl and benzyl)abietamides N-(substituted phenyl and benzyl)abietamides

1975-08-13

1977-02-22

Wyman, Daniel E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260471R, 260518R, 260518A, 260519, 2605145, 424309, 424317, 424320, C07C10118, C07C101453, C07C10319, A61K 3116

Patent

active

040092062

ABSTRACT:
Substituted N-phenyl and N-benzyl abietamide derivatives, including the dehydro-, dihydro-, and tetrahydroabietamide derivatives, are cholesterol lowering agents. The abietamide derivatives, of which N-(2,6-dimethylphenyl)-.DELTA..sup.8 -dihydroabietamide is a typical example, are produced by the reaction of abietic acid, dehydroabietic acid, dihydroabietic acid, tetrahydroabietic acid and/or active derivatives thereof with a substituted aniline or benzylamine.

REFERENCES:
patent: 2201237 (1940-05-01), Littmann
patent: 3281453 (1966-10-01), Weil et al.
Kanno, CA 56:7366h (1962).
Geigy A.-G., CA 66:47447d (1967).
Vrbovsky, CA 77:43376j (1972).

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