N-substituted nicotinamide 1-oxide as histamine H.sub.2 receptor

Details N-substituted nicotinamide 1-oxide as histamine H.sub.2 receptor N-substituted nicotinamide 1-oxide as histamine H.sub.2 receptor

1983-08-12

1985-04-30

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 586, 544131, 544364, 544365, 546193, 546194, 546256, 546261, 546316, 514222, 514234, 514318, 514335, 514343, 514355, A61K 31455, C07D40112

Patent

active

045144087

ABSTRACT:
N-substituted nicotinamide 1-oxide having histamine H.sub.2 receptor blocking activity of formula ##STR1## wherein X is a nitrogen atom or a CH group and Am represents a mono- or disubstituted amino group, a pyrrolidino, morpholino, thiomorpholino, hexamethyleneimino group, or an optionally substituted piperidino or piperazino group; their salts; a process for their preparation; and pharmaceutical compositions containing them as active ingredients.

REFERENCES:
patent: 4309433 (1982-01-01), Hirai et al.
Bickel, M., Pharm. Rev., 21(4), p. 348, (1969).

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