Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-01-29
1998-10-06
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540522, C07D22314, C07D22316, A61K 3155
Patent
active
058176543
ABSTRACT:
The present invention relates to novel N-substituted naphthofused lactams and salts thereof of the formula ##STR1## Compounds of the general formula I possess the ability to stimulate the release of endogenous growth hormone. Thus, these compounds may be used in the treatment of conditions which require stimulation of growth hormone production or secretion such as in humans with growth hormone deficiency or where increased growth hormone plasma levels are desired, for instance in elderly patients or in livestock.
REFERENCES:
Cheng et. al, "Evidence for a Role of Protein Kinase-C in His-D-Tryp-Ala-Trp-D-Phe-Lys-NH2-Induced Growth Hormone Release from Rat Primary Pituitary Cells," Endocrinology, vol. 126, No. 6, pp. 3337-3342, May 20, 1991.
Andersen Knud Erik
Hansen Birgit Sehested
Hansen Thomas Kruse
Peschke Bernd
Thogersen Henning
Kessinger Ann M.
Lambiris Elias J.
Novo Nordisk A S
Shah Mukund J.
Zelson Steve T.
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