N-substituted indole-3 glyoxylamides having anti-asthmatic antia

Details N-substituted indole-3 glyoxylamides having anti-asthmatic antia N-substituted indole-3 glyoxylamides having anti-asthmatic antia

1997-09-08

1999-12-28

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514339, 514419, 546168, 5462781, 548491, 548493, A61K 3140, C07D20904, C07D20912, C07D40106

Patent

active

060082313

ABSTRACT:
The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and immuno-suppressant/immunomodulating actions.

REFERENCES:
patent: 3135794 (1964-06-01), Archer
patent: 3801594 (1974-04-01), Poletto et al.
Glamkowski et al., "Synthesis of 3-(4-Acylaminopiperazin-1-ylalkyl)indoles as Potential Antihypertensive Agents," J. Med. Chem., vol. 20, No. 11, pp. 148-152, 1977.
Archibald et al., "1,4-Bis(2-indol-3-ylethyl)piperazines," J. Med. Chem., vol. 17, No. 7, pp. 745-747, 1974.
Domschke et al., "Notiz zur Darstellung einiger [1-Benzyl-2-methyl-5-methoxy-indolyl-(3)]-glyoxylsaureamide," vol. 94, pp. 2353-2355, 1961.
Lipp et al., "Notiz uber einige Derivate der [5-Benzyloxy-indolyl-(3)]-glyoxylsaure," Chem. Ber., vol. 91, pp. 242-243, 1957.
Chem. Abstr. 92: 128647h. CXIV. Eryshev et al., "Synthesis of anilides of indolylalkanoic acids," vol. 92, p. 673, 1980.
Chem. Abstr. 120:125105r Evans et al., "Probing the 5-HT3 receptor site using novel indole-3-glyoxylic acid derivatves," vol. 120, p. 123, 1994.
Chem. Abstr. 115007v American Home Products, "Therapeutic bis(indolyl) compounds," vol. 70, p. 15007, 1969.
Chem. Abstr. 37598x Podwinski, "Synthesis of some 5-benzyloxyindole-3-glyoxylic acid amides," vol. 70, p. 327, 1969.
Chem. Abstr. 9293 Sterling Drug Inc., "Indolylpiperazines," vol. 60, 1964.
Chem. Abstr. 3871 P'eng et al., "Synthesis of derivatives of 5,6-disubstituted 3-(Beta-aminoethyl)-indole," vol. 65, 1966.
Chem. Abstr. 53968m Bertaccini et al., "Synthesis and Pharmacological activity of some 5-methoxyindole derivatives occurring in nature," vol. 67, p. 5069, 1967.
Chem. Abstr. 87491p Brewster et al., "Antihypertensive 1,4-bis(2-indol-3-ylethyl)piperazines," vol. 79, p. 27, 1973.
Chem. Abstr. 86: 106379w Alvarez et al., "3-(2-Aminoethyl)indole derivatives," vol. 86, p. 491, 1977.
Evans et al., "Probing the 5-HT3 receptor site using novel indole-3-glyoxylic acid derivatives," Med. Chem. Res., 3(5-6), pp. 386-406, 1993.

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