N-Substituted imidazole derivatives, and their use

Details N-Substituted imidazole derivatives, and their use N-Substituted imidazole derivatives, and their use

1980-11-26

1981-09-08

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424250, 548336, 544370, A61K 31415, A61K 31495, C07D40300, C07D40514

Patent

active

042884489

ABSTRACT:
An N-substituted imidazole compound of the formula: ##STR1## wherein R and R' are independently a phenyl group optionally substituted with one or more halogen, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, C.sub.1 -C.sub.8 alkylthio, phenyl, phenoxy, phenylthio, hydroxyl, trifluoromethyl, amino, carbamoyl, di(C.sub.1 -C.sub.8) alkylamino, C.sub.1 -C.sub.8 alkanoylamino, nitro, cyano, carboxy, C.sub.1 -C.sub.8 alkoxycarbonyl, C.sub.1 -C.sub.8 alkylsulfonyloxy or C.sub.1 -C.sub.8 alkanoylpiperazino groups; a C.sub.1 -C.sub.15 alkyl group or a phenyl (C.sub.1 -C.sub.2) alkyl group optionally bearing halogen on the benzene ring, and its acid-addition salts, which is useful as an antifungal agent.

REFERENCES:
patent: 3468902 (1969-09-01), Gamaliel Beaman et al.
patent: 3493582 (1970-02-01), Hoffer
patent: 3705172 (1972-12-01), Buchel et al.
patent: 3705172 (1972-12-01), Buchel et al.
Godefroi et al., J. Med. Chem., 12, 784-791, 1969.
J. Med. Chem., 12, 784-791 (1969).

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