Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1977-08-22
1980-08-19
Ford, John M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
26032613B, 546 66, 546 85, 546 86, A61K 31445, C07D47106
Patent
active
042184533
ABSTRACT:
The invention relates to new products, in the form of bases or salts, derivatives of hexahydro-6-canthinone which may be substituted and are represented by the general formula: ##STR1## in which R.sub.1 represents a hydrogen atom or hydroxy, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 acyloxy, methoxy or halo radical and R.sub.2 represents a hydrogen atom or straight or branched C.sub.1 -C.sub.5 alkyl radical with the proviso that R.sub.1 is not hydrogen or hydroxy in the 8-position when R.sub.2 is methyl or R.sub.1 is not methoxy in the 10-position when R.sub.2 is hydrogen. The new products are especially useful for treating cardio-circulatory, cerebro-vascular and respiratory insufficiencies.
The invention also relates to a process in which the hexahydro-6-canthinone compounds are obtained by treating a N.sub.b -alkyltryptamine with .beta.-formylpropionic acid in an aromatic hydrocarbon at the reflux temperature of the reaction medium.
REFERENCES:
Taborsky, R., et al., J. Med. Chem., 7, 135-141, (1964).
Laronze, J., Dr. of Science Thesis, Reims, 12/18/74.
Yates, P. et al., J. Am. Chem. Soc., 95, 7842-7850, (1973).
March, J., Advanced Organic Chemistry, McGraw Hill, New York, 1968, pp. 335-336.
Ford John M.
Schwartz Richard A.
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