N-substituted heterocyclic derivatives and preparation thereof

Details N-substituted heterocyclic derivatives and preparation thereof N-substituted heterocyclic derivatives and preparation thereof

1974-06-28

1978-03-21

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029366, 424267, C07D40104

Patent

active

040803287

ABSTRACT:
Novel N-substituted heterocyclic derivatives represented by the formula, ##STR1## wherein R is hydrogen or lower alkanoyl; R.sub.1 is hydrogen, lower alkyl, lower alkoxy, halogen, nitro, trifluoromethyl, amino or N-lower alkanoylamino; R.sub.2 is hydrogen, halogen, amino or N-lower alkanoylamino; W is oxygen, sulfur, sulfinyl or sulfonyl; and Y is ##STR2## (wherein R.sub.3 is hydrogen, lower alkyl or lower alkanoyl; and R.sub.4 is hydrogen, halogen or lower alkyl), and pharmaceutically acceptable salts thereof, which have excellent anti-inflammatory, analgesic, sedative, anti-convulsive or anti-hypertensive activities.

REFERENCES:
patent: 3196157 (1965-07-01), Janssen
patent: 3225052 (1965-12-01), Janssen
patent: 3238216 (1966-03-01), Janssen
patent: 3818017 (1974-06-01), Janssen et al.
patent: 3894030 (1975-07-01), Janssen et al.

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