N-substituted guanidino acid derivatives

Details N-substituted guanidino acid derivatives N-substituted guanidino acid derivatives

1971-10-26

1976-01-27

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2604045, 260471A, 260518A, 260519, 260534R, 260558A, 260559A, 260559S, 260557R, 260561K, 260562N, 424320, C07C10330

Patent

active

039352668

ABSTRACT:
An N-substituted guanidino acid derivatives having the following formula of ##EQU1## wherein R is an alkyl having 6 to 15 carbon atoms,. a cycloalkyl having 6 to 15 carbon atoms or an aryl(C.sub.6 to C.sub.8)alkyl(C.sub.1 to C.sub.9); A represents R.sup.1 or R.sub.2 CO--, R.sup.1 being an alkyl having 1 to 4 carbon atoms, an alkenyl having 2 to 4 carbon atoms, cyclohexyl, a phenyl containing or not containing a substitute of a lower alkyl, a halogenated lower alkyl, a lower alkoxy, hydroxy or a halogen, or a benzyl containing or not containing a substitute of a lower alkyl, a halogenated lower alkyl, a lower alkoxy, hydroxy or a halogen, and R.sup.2 being an alkyl of 1 to 3 carbon atoms, an alkenyl of 2 to 3 carbon atoms, an aryl of 6 to 8 carbon atoms or an aryl(C.sub.6 to C.sub.8)alkyl(C.sub.1 to C.sub.2); and n is an integer of 4 to 10. The present compounds are excellent in pharmacological activities, particularly in antagonism to bradykinin and histamine, and useful as anti-inflammatory agent.

REFERENCES:
patent: 3499927 (1970-03-01), Badcock et al.
patent: 3737443 (1973-06-01), Hashimoto et al.
CA. -1962, Vol. 57, 14129f, Thoai, N.V.

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