N-substituted glycine derivatives: hydroxylase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S238000, C544S240000, C560S034000, C560S051000, C560S169000, C560S125000

Reexamination Certificate

active

07608621

ABSTRACT:
The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I)which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.

REFERENCES:
patent: 2001/0007869 (2001-07-01), Bare et al.
patent: 2004/0063709 (2004-04-01), Taveras et al.
patent: 2006/0276477 (2006-12-01), Klaus et al.
Mikhail, et al., Kidney & Blood Pressure Research, 2008;31:234-246.

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