Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1994-12-21
1997-12-09
Scheiner, Toni R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
514 18, C07K 500, C07K 700, C07K 1700, A61K 3800
Patent
active
056962312
ABSTRACT:
The present invention discloses peptide aldehydes which are potent inhibitors of factor Xa, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.
REFERENCES:
patent: 4883863 (1989-11-01), Abe et al.
patent: 5380713 (1995-01-01), Balasubramaniam et al.
Szelke et al, Brazilian J. Med. Biol. Res. vol. 27 p. 1943, 1994.
Abelman Matthew Mark
Miller Todd Anthony
Nutt Ruth Foelsche
Corvas International Inc.
Huff Sheela J.
Scheiner Toni R.
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