N-substituted glycerophosphoethanolamines

Details N-substituted glycerophosphoethanolamines N-substituted glycerophosphoethanolamines

1996-12-03

1997-09-09

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

548119, A61K 31415, C07D23316, C07D40304

Patent

active

056657145

ABSTRACT:
The present invention relates to novel, therapeutically active fatty alkyl and alkenyl ether glycerophospholipids bearing a 3-(2-imidazolinyl)-2-imidazolinyl or 2-imidazolinyl substituent on the ethanolamine nitrogen, methods of using the compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing same. The novel, therapeutically active compounds and salts of the invention possess anti-tumor, anti-psoriatic, anti-inflammatory, and anti-asthma activities.

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Paltauf, F. and Hermetter, A., Methods Enzymol., vol. 197, pp. 134-149 (1991).
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Trush et al., "The Generation of Chemiluminescence by Phagocytic Cells," Methods in Enzymology (1978), 57:462-494.

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