N-substituted dimeric cyclopeptide derivatives and preparation t

Details N-substituted dimeric cyclopeptide derivatives and preparation t N-substituted dimeric cyclopeptide derivatives and preparation t

1978-09-11

1981-02-24

Ore, Dale R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, 424 14, 424365, A61K 3700, C07C10352

Patent

active

042527953

ABSTRACT:
The N-substituted dimeric cyclopeptide derivatives of formula ##STR1## in which A is a peptide residue having one to four amino acid residues; R.sup.1 is lower alkyl, phenyl or pheny(lower) alkylene; R.sup.2 is lower alkyl, cyclo(lower)alkyl or lower alkoxycarbonyl(lower)alkylene; R.sup.3 is a neutral amino acid side chain and a method for the preparation of the compounds of formula I are disclosed. The compounds of formula I are useful for treating microbial infections. Pharmaceutical compositions also are disclosed.

REFERENCES:
Degering, Organic Chemistry, 1951, pp. 145-147, 151 and 152.
Synthetic Org. Chem., 5/1953, pp. 412-415, 605 and 813.
Organic Chemistry, 1956, 2nd edition, pp. 413-416.

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