N-substituted derivatives of 4 (N-piperazinylmethyl) spiro diben

Details N-substituted derivatives of 4 (N-piperazinylmethyl) spiro diben N-substituted derivatives of 4 (N-piperazinylmethyl) spiro diben

1976-12-06

1977-09-20

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

42424856, 424250, 544121, 2602433, C07D40506

Patent

active

040496600

ABSTRACT:
Compounds of the formula ##STR1## wherein Z is --CH.sub.2 CH.sub.2 -- or --CH.dbd.CH--, and R is methyl, ethoxycarbonylmethyl or ##STR2## wherein ##STR3## is methylamino, n-propylamino, isopropylamino, dimethylamino, di(n-propyl)amino, morpholino, pyrrolidino or hexamethyleneimino. The compounds are prepared by reacting piperazine substituted with R, with 4'-bromomethyl-5,2'-spiro-dibenzocycloheptadi(or tri)ene-(1',3') dioxolan. The compounds possess cough-suppressing, spasmolytic, analgesic, respiratory analeptic, hypotensive, vasodilatory, antiarythmic, antiulcerous, antihistamine, sedative, anti-inflammatory, diuretic and antiserotonine properties.

REFERENCES:
patent: 3726900 (1973-04-01), Fauran et al.

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