N'-substituted derivatives of 4'-(N-piperazinylmethyl)spiro dibe

Details N'-substituted derivatives of 4'-(N-piperazinylmethyl)spiro dibe N'-substituted derivatives of 4'-(N-piperazinylmethyl)spiro dibe

1975-01-16

1977-09-13

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

42424856, 260268TR, C07D41314

Patent

active

040481646

ABSTRACT:
Compounds of the formula ##STR1## wherein Z is --CH.sub.2 CH.sub.2 -- or --CH=CH--, and R is methyl, ethoxycarbonylmethyl or ##STR2## wherein ##STR3## is methylamino, n-propylamino, isopropylamino, dimethylamino, di(n-propyl)amino, morpholino, pyrrolidino or hexamethyleneimino. The compounds are prepared by reacting piperazine substituted with R, with 4'-bromomethyl-5,2'-spiro-dibenzocycloheptadi- (or tri)ene-(1',3') dioxolan. The compounds possess cough-suppressing, spasmolytic, analgesic, respiratory analeptic, hypotensive, vasodilatory, antiarythmic, antiulcerous, antihistamine, sedative, anti-inflammatory, diuretic and antiserotonine properties.

REFERENCES:
patent: 3687965 (1972-08-01), Fauran et al.
patent: 3696100 (1972-10-01), Raynaud et al.
patent: 3726900 (1973-04-01), Fauran et al.
patent: 3845046 (1974-10-01), Fauran et al.

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