N-substituted derivatives of 3R,4R-ethyl-[(1-methyl-1H-imidazol-

Details N-substituted derivatives of 3R,4R-ethyl-[(1-methyl-1H-imidazol- N-substituted derivatives of 3R,4R-ethyl-[(1-methyl-1H-imidazol-

1989-11-13

1993-11-23

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548110, 5483147, A61K 31415, C07D40300

Patent

active

052644499

ABSTRACT:
The present invention relates to new carbonyl 3R, 4R-ethyl-[(1-methyl-1H-imidazol-5-yl)methyl] -2-pyrrolidinone derivatives carrying a carboxyester-type lipophilic moiety on the pyrrolidinone nitrogen. More particularly, the present invention concerns new N-substituted carbonyl-3R,4R-ethyl-[(1-methyl-1H-imidazol-5-yl) methyl]-2-pyrrolidinone derivatives of the formula (I): ##STR1## wherein R is an optionally substituted hydrocarbon group, and pharmaceutically acceptable acid addition salts thereof.
The new compounds of the formula (I) are potent ocular hypotensives that are valuable antiglaucoma agents. They are also targeted for use in the treatment of so-called dry eye.

REFERENCES:
patent: 3470197 (1969-09-01), Van Dyke
J. Pharm. Sci., 62, 2021 (1973).

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