N-substituted derivatives of 3-carboxamide and 3-thiocarboxamide

Details N-substituted derivatives of 3-carboxamide and 3-thiocarboxamide N-substituted derivatives of 3-carboxamide and 3-thiocarboxamide

1976-01-15

1977-05-17

Ford, John M.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424249, C07D25172

Patent

active

RE0292257

ABSTRACT:
Compounds of the formula ##STR1## WHERE X represents O or S and R represents lower alkyl, cycloalkyl, phenyl or substituted phenyl wherein the substituents are selected from lower alkyl, lower alkoxy, halo and sulfonyl. The compounds are prepared by reacting the [carbinolamine] ring-opened intermediate,obtained by reacting cis-1-(3-chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo (3,3,1,1.sup.3,7) decane chloride with excess aqueous sodium hydroxide, with an equivalent amount of a corresponding R isocyanate or R isothiocyanate at a low temperature to give the substituted urea or thiourea product. The compounds have antimicrobial activity.

REFERENCES:
patent: 3575974 (1971-04-01), Hodge et al.

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