N-substituted derivatives of 1-desaminovasopressin

Details N-substituted derivatives of 1-desaminovasopressin N-substituted derivatives of 1-desaminovasopressin

1984-11-16

1989-05-09

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 514807, 530315, A61K 3734, C07K 716

Patent

active

048290513

ABSTRACT:
Novel analogs of biologically active vasopressin and its synthetic analogs having improved activity are represented by the structural formula: ##STR1## wherein A hydrogen; is hydroxy or lower alkoxy, especially methoxy, B is the peptide residue of phenylalanine (Phe) or isoleucine, Gln represents the peptide residue of glutamine Asn represents the peptide residue of asparagine, E represents the peptide residue of proline (Pro), 4-thioproline (4-thioPro) or 3,4-dehydroproline (3,4-dehydroPro), FNH represents an N-substituted peptide residue of L- or D-lysine (Lys) L or D homolysine (h Lys) or L- or D-orntihine (Orn), X represents a side peptide chain consisting of one or more of Gly, L-Ala, L-Val, L-Leu, or L-Phe, Gly represents the peptide residue of glycine, and G is disulfide (--S--S--) or thioether (--CH.sub.2 S-- or --SCH.sub.2 --).

REFERENCES:
patent: 3497491 (1970-02-01), Zaoral et al.
patent: 3558590 (1971-01-01), Cort et al.
patent: 3980631 (1976-09-01), Prochazka et al.
patent: 4180501 (1979-12-01), Coy et al.
Hechter, J. Biol. Chem., 253, 3230, (1978).
Bippi, "Peptidsynthesin Am Lysin-Vasopressin", Diplomarbeit, University of Hohenheim, Germany, (1980).

Affiliated with

Also associated with

Rating

N-substituted derivatives of 1-desaminovasopressin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N-substituted derivatives of 1-desaminovasopressin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N-substituted derivatives of 1-desaminovasopressin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-90236