N-substituted cyclopeptide derivatives and preparation thereof

Details N-substituted cyclopeptide derivatives and preparation thereof N-substituted cyclopeptide derivatives and preparation thereof

1978-09-11

1980-12-02

Ore, Dale R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, C07C10352, A61K 3700

Patent

active

042370450

ABSTRACT:
The N-substituted cyclopeptide derivatives of formula I ##STR1## in which R.sup.1 is lower alkyl, R.sup.2 is lower alkyl or cyclo(lower)alkyl, R.sup.3 is a neutral amino acid side chain and Y is a peptide residue having three to nine amino acid residues and a method for the preparation of the compounds of formula I are disclosed. The compounds of formula I are useful antibacterial and antifungal agents. Pharmaceutical compositions also are disclosed.

REFERENCES:
Degering, Organic Chemistry, 1951, pp. 145-147, 151 and 152.
Synthetic Org. Chem., 5/1953, pp. 412-415, 605 and 813.
Organic Chemistry, 1956, 2nd Ed. pp. 413-416.

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