N-Substituted cyclopeptide derivatives

Details N-Substituted cyclopeptide derivatives N-Substituted cyclopeptide derivatives

1980-06-30

1982-09-28

Ore, Dale R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, 424 14, 424357, A61K 3700

Patent

active

043518281

ABSTRACT:
The N-substituted cyclopeptide derivatives of formula I ##STR1## in which R.sup.1 is lower alkyl, R.sup.2 is lower alkyl or cyclo(lower)alkyl, R.sup.3 is a neutral amino acid side chain and Y is a peptide residue having three to nine amino acid residues and a method for the preparation of the compounds of formula I are disclosed. The compounds of formula I are useful antibacterial and antifungal agents. Pharmaceutical compositions also are disclosed.

REFERENCES:
Degering, Organic Chemistry, 1951, pp. 145-147, 151 and 152.
Synthetic Org. Chem.; 5/1953, pp. 412-415, 605 and 813.
Organic Chemistry, 1956, 2nd Ed., pp. 413-416.

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